Cl-amidine hydrochloride
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4) . Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR) -16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
Product Specifications
CAS Number
1373232-26-8
Purity
>98% (HPLC)
Solubility
H2O:50 mg/mL (143.99 mM; Need ultrasonic) ; DMSO:19.23 mg/mL (55.38 mM; Need ultrasonic)
Smiles
O=C (N[C@H] (C (N) =O) CCCNC (CCl) =N) C1=CC=CC=C1.[H]Cl
Molecular Formula
C14H20Cl2N4O2
Molecular Weight
347.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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