UCB-9260
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. (In Vitro) :UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively. (In Vivo) :UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.
Product Specifications
CAS Number
1515888-53-5
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
OC (C1=CC=NC=C1) C2=NC3=CC=C (C4=CN (C) N=C4) C=C3N2CC5=CC (C) =CC=C5C
Molecular Formula
C26H25N5O
Molecular Weight
423.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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