VER-246608
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively) .VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
Product Specifications
CAS Number
1684386-71-7
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (180.84 mM; Need ultrasonic)
Smiles
O=C (C1=CC=C (O) C=C1O) N (CC2=CC=C (CNC (C (F) F) =O) C=C2) C (C=C3) =CC=C3C4=NC (Cl) =NC=C4C
Molecular Formula
C28H23ClF2N4O4
Molecular Weight
552.96
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
St6galnac1 sgRNA CRISPR Lentivector (Mouse) (Target 2)
GPC5, NT (GPC5, Glypican-5, Secreted glypican-5) (MaxLight 550) discontinued