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JHU 37152

JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

Product Specifications

CAS Number

2369979-67-7

Purity

>98% (HPLC)

Solubility

DMSO:72 mg/mL (200.65 mM) ; Ethanol:24 mg/mL (66.88 mM)

Smiles

FC1=C2C (NC3=CC=C (Cl) C=C3N=C2N4CCN (CC) CC4) =CC=C1

Molecular Formula

C19H20ClFN4

Molecular Weight

358.85

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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