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GSK046

GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins (IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively) . It has immunomodulatory activity.

Product Specifications

CAS Number

2474876-09-8

Product Name Alternative

IBET-BD2

Purity

>98% (HPLC)

Solubility

DMSO:83.33 mg/mL (201.05 mM; Need ultrasonic)

Smiles

O=C (N[C@@H]1CC[C@@H] (O) CC1) C2=CC (O[C@H] (C3=CC=CC=C3) C) =C (NC (C) =O) C (F) =C2

Molecular Formula

C23H27FN2O4

Molecular Weight

414.48

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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