GSK046
GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins (IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively) . It has immunomodulatory activity.
Product Specifications
CAS Number
2474876-09-8
Product Name Alternative
IBET-BD2
Purity
>98% (HPLC)
Solubility
DMSO:83.33 mg/mL (201.05 mM; Need ultrasonic)
Smiles
O=C (N[C@@H]1CC[C@@H] (O) CC1) C2=CC (O[C@H] (C3=CC=CC=C3) C) =C (NC (C) =O) C (F) =C2
Molecular Formula
C23H27FN2O4
Molecular Weight
414.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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