BSJ-4-116
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly (adenylation) .
Product Specifications
CAS Number
2519823-34-6
Purity
>98% (HPLC)
Solubility
DMSO:250 mg/mL (298.55 mM; Need ultrasonic)
Smiles
O=C (NCCCCCCCN1C[C@H] (NC2=NC=C (Cl) C (NC3=CC=CC=C3S (=O) (C (C) C) =O) =N2) CCC1) COC4=CC=CC (C (N5C (CC6) C (NC6=O) =O) =O) =C4C5=O
Molecular Formula
C40H49ClN8O8S
Molecular Weight
837.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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