Conoidin A
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) . Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.
Product Specifications
CAS Number
18080-67-6
Purity
>98% (HPLC)
Solubility
DMSO:14.29 mg/mL (41.06 mM; Need ultrasonic)
Smiles
[O-][N+]1=C (CBr) C (CBr) =[N+] ([O-]) C2=CC=CC=C21
Molecular Formula
C10H8Br2N2O2
Molecular Weight
347.99
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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