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Conoidin A

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) . Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.

Product Specifications

CAS Number

18080-67-6

Purity

>98% (HPLC)

Solubility

DMSO:14.29 mg/mL (41.06 mM; Need ultrasonic)

Smiles

[O-][N+]1=C (CBr) C (CBr) =[N+] ([O-]) C2=CC=CC=C21

Molecular Formula

C10H8Br2N2O2

Molecular Weight

347.99

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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