EN6
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase) .
Product Specifications
CAS Number
1808714-73-9
Purity
>98% (HPLC)
Solubility
DMSO: 4.63 mg/mL (12.57 mM; Need ultrasonic) ; Ethanol: 1.10 mg/mL (2.99 mM; ultrasonic and warming and heat to 60°C)
Smiles
C=CC (Nc (cc (cc1) NC (c2cn (-c (cccc3) c3F) nc2) =O) c1F) =O
Molecular Formula
C19H14F2N4O2
Molecular Weight
368.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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