Capromorelin Tartrate
Capromorelin Tartrate is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a) . (In Vitro) :Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM. (In Vivo) :Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F (rat) =65%, F (dog) =44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.
Product Specifications
CAS Number
193273-69-7
Product Name Alternative
CP 424391-18
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (152.51 mM)
Smiles
O=C ([C@@H] ([C@@H] (O) C (O) =O) O) O.CC (C) (N) C (N[C@H] (COCC1=CC=CC=C1) C (N (C[C@]23CC4=CC=CC=C4) CCC2=NN (C) C3=O) =O) =O
Molecular Formula
C32H40N5O10
Molecular Weight
655.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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