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Tolebrutinib

Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor (IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively) . It exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS) .

Product Specifications

CAS Number

1971920-73-6

Product Name Alternative

SAR442168 | PRN2246

Purity

>98% (HPLC)

Solubility

DMSO:100 mg/mL (219.53 mM; Need ultrasonic)

Smiles

C=CC (N (CCC1) C[C@@H]1N (c (ccnc1N) c1N1c (cc2) ccc2Oc2ccccc2) C1=O) =O

Molecular Formula

C26H25N5O3

Molecular Weight

455.51

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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