JNJ-63576253
JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) .
Product Specifications
CAS Number
2110426-27-0
Product Name Alternative
TRC253
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
C1CC2 (C1) C (=O) N (C (=S) N2C3=CN=C (C=C3) OC4CCNCC4) C5=CC (=C (N=C5) C#N) C (F) (F) F
Molecular Formula
C23H21F3N6O2S
Molecular Weight
502.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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