Plecanatide

Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. (In Vitro) :Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells. (In Vivo) :Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice.Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS) -induced colitis in BDF-1 mice.

Product Specifications

CAS Number

467426-54-6

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (59.46 mM)

Smiles

CC (C) C[C@H] (NC ([C@H]1NC (CNC ([C@@H] (NC ([C@H]2NC ([C@H] (C) NC ([C@@H] (NC ([C@H] (CC (N) =O) NC ([C@@H] (NC ([C@H] (CSSC1) NC ([C@H] (CC (C) C) NC ([C@H] (CCC (O) =O) NC ([C@H] (CSSC2) NC ([C@H] (CCC (O) =O) NC ([C@H] (CC (O) =O) NC ([C@@H] (N) CC (N) =O) =O) =O) =O) =O) =O) =O) =O) C (C) C) =O) =O) C (C) C) =O) =O) =O) [C@@H] (C) O) =O) =O) =O) C (O) =O