PD146176
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO), it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Product Specifications
CAS Number
4079-26-9
Product Name Alternative
NSC168807
Purity
>98% (HPLC)
Solubility
DMSO:25 mg/mL (105.34 mM; Need ultrasonic) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
C1C2=C (C3=CC=CC=C3S1) NC4=CC=CC=C24
Molecular Formula
C15H11NS
Molecular Weight
237.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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