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PD146176

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO), it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

Product Specifications

CAS Number

4079-26-9

Product Name Alternative

NSC168807

Purity

>98% (HPLC)

Solubility

DMSO:25 mg/mL (105.34 mM; Need ultrasonic) ; H2O:< 0.1 mg/mL (insoluble)

Smiles

C1C2=C (C3=CC=CC=C3S1) NC4=CC=CC=C24

Molecular Formula

C15H11NS

Molecular Weight

237.32

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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