PIN1 inhibitor API-1
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) . PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
Product Specifications
CAS Number
680622-70-2
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:250 mg/mL (682.50 mM; Need ultrasonic)
Smiles
C1=CC (=CC=C1CNC (=O) C (F) (F) F) COC2=NC (=NC3=C2NC=N3) N
Molecular Formula
C15H13F3N6O2
Molecular Weight
366.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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