D-AP5
D-AP5 is a NMDA receptor antagonist. (In Vivo) :D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented.D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze.
Product Specifications
CAS Number
79055-68-8
Product Name Alternative
D-APV | D-2-Amino-5-phosphonovaleric acid
Purity
>98% (HPLC)
Solubility
H2O:27.78 mg/mL (140.92 mM; Need ultrasonic) ; Ethanol:< 1 mg/mL (insoluble)
Smiles
C (C[C@H] (C (=O) O) N) CP (=O) (O) O
Molecular Formula
C5H12NO5P
Molecular Weight
197.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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