Bmf (CT) Polyclonal Antibody

Bmf (CT) [This rabbit antibody recognizes an epitope of aa 171-184 at the C-terminus of human Bmf (Bcl-2-Modifying Factor), a novel BH3-only protein.]<br>This antibody recognizes an epitope at the C-terminus of human Bmf (Bcl-2- Modifying Factor), a novel BH3-only protein. In healthy cells, Bmf associates with the dynein light chain 2 component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiaing the downstream apoptotic program. Bmf is constitutively expressed in many tissues.