Prunasin

Prunasin is an orally active cyanogenic glucoside and the main metabolite of Amygdalin (HY-N0190) . Prunasin can specifically inhibit rat DNA polymerase β (IC50: 98 μM) . Prunasin has anti-inflammatory and anti-fibrotic activities. Prunasin can be used in the research of diseases such as liver fibrosis[1][2].

Product Specifications

CAS Number

[99-18-3]

UNSPSC

12352005

Hazard Statement

H301, H360

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/prunasin.html

Purity

99.56

Solubility

H2O : ≥ 50 mg/mL

Smiles

N#C[C@@H](C1=CC=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO

Molecular Formula

C14H17NO6

Molecular Weight

295.29

Precautions

H301, H360

References & Citations

[1]Mizushina Y, et al. The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta. J Biochem. 1999;126 (2) :430-436.|[2]Zhang C, et al. Pharmacokinetics and anti-liver fibrosis characteristics of amygdalin: Key role of the deglycosylated metabolite prunasin. Phytomedicine. 2022 May;99:154018.