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Leptomycin B

Leptomycin B is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.

Product Specifications

CAS Number

87081-35-4

Product Name Alternative

CI 940 | LMB

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : ≥ 100 mg/mL (184.94 mM)

Smiles

CC/C (/C=C/[C@@H] ([C@@H] (C) C=C1) OC1=O) =C/[C@H] (C) C/C=C/C (/C) =C/[C@@H] (C) C ([C@@H] (C) [C@@H] ([C@@H] (C) C/C (/C) =C/C (O) =O) O) =O

Molecular Formula

C33H48O6

Molecular Weight

540.73

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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