GS-143
GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.
Product Specifications
CAS Number
916232-21-8
Product Name Alternative
GS 143 | GS143
Purity
>98% (HPLC)
Solubility
DMSO:40 mg/mL (85.75 mM; Need ultrasonic)
Smiles
OC (c (cc1) ccc1N (C1=O) N=C (Cc2ccccc2) C1=Cc1ccc (-c (cccc2) c2F) o1) =O
Molecular Formula
C28H19FN2O4
Molecular Weight
466.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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