Avoralstat
Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro) :C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE) .
Product Specifications
CAS Number
918407-35-9
Product Name Alternative
BCX4161
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (97.36 mM; Need ultrasonic)
Smiles
COc (c (C=C) c1) cc (-c2ccc (C (NCC3CC3) =O) nc2C (O) =O) c1C (Nc (cc1) ccc1C (N) =N) =O
Molecular Formula
C28H27N5O5
Molecular Weight
513.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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