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(+) -PD 128907 hydrochloride

(+) -PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D3 receptors, 179, 770 n M for human and rat D3 receptors, respectively.

Product Specifications

CAS Number

300576-59-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/__addition__-PD_128907_hydrochloride.html

Purity

98.92

Solubility

DMSO : 20.83 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

CCCN1[C@@]2([H])[C@@](OCC1)([H])C3=CC(O)=CC=C3OC2.Cl

Molecular Formula

C14H20ClNO3

Molecular Weight

285.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Collins GT, et al. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. J Pharmacol Exp Ther. 2005 Jul;314 (1) :310-9.|[2]Bristow LJ, et al. The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+) -PD 128907, in the rat. Neuropharmacology. 1996 Mar;35 (3) :285-94.|[3]Zapata A, et al. Selective D3 receptor agonist effects of (+) -PD 128907 on dialysate dopamine at low doses. Neuropharmacology. 2001 Sep;41 (3) :351-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D2 Receptor; D3 Receptor

Available Sizes

Frequently Asked Questions

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