Prekallikrein Heavy Chain Monoclonal Antibody
Product Specifications
NCBI Gene ID
125184
Storage Conditions
This antibody is stable for at least one (1) year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.
Specificity
Anti-Prekallikrein Heavy Chain [MurineMAb recognizes the heavy chain of human prekallikrein.]<br>This antibody specifically recognizes in human plasma two variants (88 kDa and 85 kDa) of prekallikrein and its activation products kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80% and 55%,respectively. This antibody does not cross-react with tissue kallikrein.
Short Name
[Prekallikrein Heavy Chain]
NCBI Accession Number
AAA60153
Uniprot Accession Number
P03952.1
CAS Number
9007-83-4
Available Sizes
Curated Selection
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