TMDJ-035

TMDJ-035 is a selective RyR2 inhibitor. TMDJ-035 suppresses abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035is a tool for studying the mechanism and dynamics of RyR2 channel gating[1].

Product Specifications

CAS Number

[2681302-83-8]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tmdj-035.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=CC(C2=NN(CC(N(C3=CC=C(F)C=C3)C)=O)N=N2)=C1

Molecular Formula

C16H12F3N5O

Molecular Weight

347.29

References & Citations

[1]Ryosuke Ishida, et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European Journal of Medicinal Chemistry