DT2216
DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC) . DT2216 targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.
Product Specifications
CAS Number
2365172-42-3
Purity
>98%
Smiles
CC1 (CC (CN2CCN (C3C=CC (C (=O) NS (=O) (C4C=CC (N[C@H] (CCN5CCN (C (=O) CCCCCC (=O) N[C@H] (C (=O) N6C[C@H] (O) C[C@H]6C (=O) N[C@@H] (C) C6C=CC (C7SC=NC=7C) =CC=6) C (C) (C) C) CC5) CSC5C=CC=CC=5) =C (S (=O) (=O) C (F) (F) F) C=4) =O) =CC=3) CC2) =C (C2C=CC (Cl) =CC=2) CC1) C
Molecular Formula
C77H96ClF3N10O10S4
Molecular Weight
1542.36
Notes
For research use only.
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