COG 133
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM) .
Product Specifications
CAS Number
514200-66-9
Purity
>98%
Smiles
[Ac-LRVRLASHLRKLRKRLL-NH2]
Molecular Formula
C99H182F3N37O21
Molecular Weight
2283.78
Notes
For research use only.
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