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Mefuparib hydrochloride (CVL218)

Mefuparib (CVL218) hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.CVL218 was more potent than Remdesivir in blocking Coronavirus infection of cells and equally as potent as Remdesivir in blocking replication of virus once it has entered the cells.

Product Specifications

CAS Number

1449746-00-2

Field of Research

Pharmacology & Drug Discovery

Purity

>98%

Smiles

O=C (C1=C (OC (C2=CC=C (CNC) C=C2) =C3) C3=CC (F) =C1) N.[H]Cl

Molecular Formula

C17H16ClFN2O2

Molecular Weight

334.775

References & Citations

María Ángeles Márquez-Moñino 1, Clara M Santiveri 2, Patricia de León 3, Sergio Camero 1, Ramón Campos-Olivas 2, M Ángeles Jiménez 1, Margarita Sáiz 3, Beatriz González 4, José Manuel Pérez-Cañadillas The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity Structure, (2024)

Pubmed id

39541975

Notes

For research use only.

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