Mefuparib hydrochloride (CVL218)
Mefuparib (CVL218) hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.CVL218 was more potent than Remdesivir in blocking Coronavirus infection of cells and equally as potent as Remdesivir in blocking replication of virus once it has entered the cells.
Product Specifications
CAS Number
1449746-00-2
Field of Research
Pharmacology & Drug Discovery
Purity
>98%
Smiles
O=C (C1=C (OC (C2=CC=C (CNC) C=C2) =C3) C3=CC (F) =C1) N.[H]Cl
Molecular Formula
C17H16ClFN2O2
Molecular Weight
334.775
References & Citations
María Ángeles Márquez-Moñino 1, Clara M Santiveri 2, Patricia de León 3, Sergio Camero 1, Ramón Campos-Olivas 2, M Ángeles Jiménez 1, Margarita Sáiz 3, Beatriz González 4, José Manuel Pérez-Cañadillas The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity Structure, (2024)
Pubmed id
39541975
Notes
For research use only.
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