S-Methylglutathione

S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1[2].

Product Specifications

CAS Number

[2922-56-7]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Glyoxalase (GLO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s-methylglutathione.html

Concentration

10mM

Purity

99.40

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CNC([C@H](CSC)NC(CC[C@@H](C(O)=O)N)=O)=O

Molecular Formula

C11H19N3O6S

Molecular Weight

321.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Foye WO, et al. Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents. J Pharm Sci. 1984 Apr;73 (4) :559-61.|[2]Milos I. Djuran, et al. Reactivity of chloro- and aqua (diethylenetriamine) platinum (II) ions with glutathione, S-methylglutathione, and guanosine 5'-monophosphate in relation to the antitumor activity and toxicity of platinum complexes. Inorg. Chem. 1991, 30, 12, 2648–2652