HS-1371
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1].
Product Specifications
CAS Number
2158197-70-5
Product Name Alternative
Ro 40-7591,Hydroxytolbutamide-d9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/HS-1371.html
Purity
99.86
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1
Molecular Formula
C24H24N4O
Molecular Weight
384.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50 (9) :125.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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