Seocalcitol
Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM.
Product Specifications
CAS Number
134404-52-7
Product Name Alternative
EB 1089
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
VD/VDR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Seocalcitol.html
Purity
99.14
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@H]1C[C@@H](C(/C(C1)=C\C=C2[C@@]3(CC[C@@H]([C@]3(CCC\2)C)[C@@H](/C=C/C=C/C(CC)(CC)O)C)[H])=C)O
Molecular Formula
C30H46O3
Molecular Weight
454.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Wiberg K, et al. Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro. Bone. 1995 Oct;17 (4) :391-5.|[2]Roy S, et al. Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase. J Bone Miner Res. 1995 Dec;10 (12) :1951-9|[3]Bondza-Kibangou P, et al. Antioxidants and doxorubicin supplementation to modulate CD14 expression and oxidative stress induced by vitamin D3 and seocalcitol in HL60 cells. Oncol Rep. 2007 Dec;18 (6) :1513-9.|[4]Ghous Z, et al. Inhibition of hepatocellular cancer by EB1089: in vitro and in vivo study. Anticancer Res. 2008 Nov-Dec;28 (6A) :3757-61.|[5]Ormerod AK, et al. The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp Lung Res. 2008 May;34 (4) :155-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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