Tecalcet (Hydrochloride)

Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR) . Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].

Product Specifications

CAS Number

[177172-49-5]

Product Name Alternative

R-568 (hydrochloride) ; NPS R-568

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tecalcet-hydrochloride.html

Purity

99.66

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@H](NCCCC1=CC=CC=C1Cl)C2=CC=CC(OC)=C2.[H]Cl

Molecular Formula

C18H23Cl2NO

Molecular Weight

340.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100 (12), 2977-2983 (1997) .|[2]Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10 (3), 275-279 (1996) .|[3]Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95 (7), 4040-4045 (1998) .