I-BET787
Product Specifications
UNSPSC Description
I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i-bet787.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=NC(Cl)=CN2CC3CCOCC3)=CN(C1=O)C
Molecular Weight
321.80
References & Citations
[1]Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67(12):10464-10489.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163729/I-BET787-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163729/I-BET787-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2201082-98-4
Available Sizes
Curated Selection
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