I-BET787

I-BET787 is a orally active BET bromine domain inhibitor with pIC50s of 7.1 and 5.9 for BRD4 BD1 and BRD4 BD2, respectively. I-BET787 has anti-inflammatory activity in mice[1].

Product Specifications

CAS Number

[2201082-98-4]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/i-bet787.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(C2=NC(Cl)=CN2CC3CCOCC3)=CN(C1=O)C

Molecular Formula

C16H20ClN3O2

Molecular Weight

321.80

References & Citations

[1]Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67 (12) :10464-10489.