I-BET787
I-BET787 is a orally active BET bromine domain inhibitor with pIC50s of 7.1 and 5.9 for BRD4 BD1 and BRD4 BD2, respectively. I-BET787 has anti-inflammatory activity in mice[1].
Product Specifications
CAS Number
[2201082-98-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i-bet787.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=NC(Cl)=CN2CC3CCOCC3)=CN(C1=O)C
Molecular Formula
C16H20ClN3O2
Molecular Weight
321.80
References & Citations
[1]Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67 (12) :10464-10489.
Shipping Conditions
Room Temperature
Storage Conditions
RT, sealed storage, away from moisture and light
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6292314-01 0.2 mL
DLG7, ID (DLGAP5, DLG7, KIAA0008, Disks large-associated protein 5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein) (FITC)
Ask
View Details MBS6292314-02 5x 0.2 mL
DLG7, ID (DLGAP5, DLG7, KIAA0008, Disks large-associated protein 5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein) (FITC)
Ask
View Details 