I-BET787
I-BET787 is a orally active BET bromine domain inhibitor with pIC50s of 7.1 and 5.9 for BRD4 BD1 and BRD4 BD2, respectively. I-BET787 has anti-inflammatory activity in mice[1].
Product Specifications
CAS Number
[2201082-98-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i-bet787.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=NC(Cl)=CN2CC3CCOCC3)=CN(C1=O)C
Molecular Formula
C16H20ClN3O2
Molecular Weight
321.80
References & Citations
[1]Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67 (12) :10464-10489.
Shipping Conditions
Room Temperature
Storage Conditions
RT, sealed storage, away from moisture and light
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
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