WHI-P258

WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

Product Specifications

CAS Number

[21561-09-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/whi-p258.html

Purity

99.91

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC

Molecular Formula

C16H15N3O2

Molecular Weight

281.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5 (6) :1569-82.|[2]Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276 (21) :17815-22.