WHI-P258
Product Specifications
UNSPSC Description
WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
Target Antigen
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/whi-p258.html
Purity
99.61
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC
Molecular Weight
281.31
References & Citations
[1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.|[2]Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108419/WHI-P258-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108419/WHI-P258-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
21561-09-1
Available Sizes
Curated Selection
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