JAK2/FLT3-IN-3
JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].
Product Specifications
CAS Number
3038183-53-5
UNSPSC
12352005
Target
Apoptosis; FLT3; JAK
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak2-flt3-in-3.html
Smiles
O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C
Molecular Formula
C34H45N9O2
Molecular Weight
611.78
References & Citations
[1]Sicong Xu, et al. 2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 May:134:106442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3
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