NPE-caged-AppNHp
(NPE-caged-AMPPNP)
Product Specifications
CAS Number
116271-21-7
Product Name Alternative
(NPE-caged-AMPPNP), Adenosine-5'-[ (β, γ) -imido]triphosphate, P3- (1- (2-nitrophenyl) -ethyl) -ester, Triethylammonium salt
Concentration
10 mM-11 mM
Purity
≥ 95% (HPLC)
Form
Solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
Smiles
[C@@H]1 ([C@H] ([C@@H] (O[C@@H]1COP (=O) (OP (=O) (NP (=O) (OC (c1ccccc1[N+] (=O) [O-]) C) O) O) O) n1c2c (nc1) c (ncn2) N) O) O
Molecular Formula
C18H24N7O14P3
Molecular Weight
Theoretical MW: 655.35 g/mol (free acid) ; Detected MW: 655.06 g/mol (free acid)
Storage Conditions
Store at -20 °C
Notes
For research use only.
Applications Notes
Agonistic ligand, mainly for nucleoside receptor A1 Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors. The caged form is protected during uptake and transport in animal experiments and can be well-directed released through activation at the target tissue. Spectroscopic Propertie: λmax 260 nm, ε 18.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5) .
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