Chlorpheniramine (maleate)
Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].
Product Specifications
CAS Number
113-92-8
Product Name Alternative
Chlorphenamine maleate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Chlorpheniramine-maleate.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Smiles
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.O=C(O)/C=C\C(O)=O
Molecular Formula
C20H23ClN2O4
Molecular Weight
390.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35 (2) : p. 187-94.|[2]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.|[3]Iemura, R., et al., Synthesis of 2- (4-substituted-1-piperazinyl) benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29 (7) : p. 1178-83.|[4]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[5]Kim J, et al. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Chemosphere. 2019 Jun:225:378-387.|J Pharm Sci. 2019 Sep;108 (9) :2895-2904.|J Inflamm Res. 2025 Jun 17:18:7907-7919.|Neuropharmacology. 2025 Nov 1:278:110593.
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