7α,25-Dihydroxycholesterol

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) . 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM) . 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].

Product Specifications

CAS Number

[64907-22-8]

Product Name Alternative

7α,25-OHC

UNSPSC

12352211

Target

EBI2/GPR183; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/7-alpha-25-dihydroxycholesterol.html

Purity

99.88

Solubility

DMSO : 4.55 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1

Molecular Formula

C27H46O3

Molecular Weight

418.65

References & Citations

[1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475 (7357) :519-23.|[2]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475 (7357) :524-7.