7α,25-Dihydroxycholesterol
Product Specifications
UNSPSC Description
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
Target Antigen
EBI2/GPR183; Endogenous Metabolite
Type
Natural Products
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7-alpha-25-dihydroxycholesterol.html
Purity
99.0
Solubility
DMSO : 4.55 mg/mL (ultrasonic)|Ethanol : < 1 mg/mL
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1
Molecular Weight
418.65
References & Citations
[1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.|[2]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113962/7α-25-Dihydroxycholesterol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113962/7α-25-Dihydroxycholesterol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
64907-22-8
Available Sizes
Curated Selection
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