Ac-YVAD-cmk

Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE) ) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].

Product Specifications

CAS Number

[178603-78-6]

Product Name Alternative

Caspase-1 Inhibitor II

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-yvad-cmk.html

Purity

98.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@H](NC(C)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)C(C)C)=O)C=C1

Molecular Formula

C24H33ClN4O8

Molecular Weight

540.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14 (10) :1245-1255. Published 2018 Jul 13. |[2]Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. |[3]Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131 (3) :383-386.