Numidargistat (dihydrochloride)
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Product Specifications
Product Name Alternative
CB-1158 (dihydrochloride) ; INCB01158 (dihydrochloride)
UNSPSC
12352005
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CB-1158_Hydrochloride.html
Concentration
10mM
Purity
98.50
Solubility
DMSO : 55 mg/mL (ultrasonic) |H2O : 37.78 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl
Molecular Formula
C11H24BCl2N3O5
Molecular Weight
360.04
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
1,2,4-Benzenetricarboxylic Acid 1,2-Bis(2-ethylhexyl) Ester
CD19 (CVID3/429), CF740 conjugate, 0.1mg/mL
MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL
CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) (Ki-1/1747R), 1mg/mL
Glutathione Peroxidase 1 (GPX1) (C-term) Rabbit Polyclonal Antibody
