Numidargistat (dihydrochloride)
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Product Specifications
Product Name Alternative
CB-1158 (dihydrochloride) ; INCB01158 (dihydrochloride)
UNSPSC
12352005
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CB-1158_Hydrochloride.html
Concentration
10mM
Purity
98.50
Solubility
DMSO : 55 mg/mL (ultrasonic) |H2O : 37.78 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl
Molecular Formula
C11H24BCl2N3O5
Molecular Weight
360.04
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Available Sizes
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