Glutaminase C-IN-1
Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts[1][2].
Product Specifications
CAS Number
[311795-38-7]
Product Name Alternative
Compound 968
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Glutaminase-C-IN-1.html
Purity
99.89
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C(C(C2=CC=C(N(C)C)C(Br)=C2)NC3=C4C5=CC=CC=C5C=C3)=C4CC(C)(C)C1
Molecular Formula
C27H27BrN2O
Molecular Weight
475.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112 (2) :394-9.|[2]Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18 (3) :207-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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