Glutaminase C-IN-1

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts[1][2].

Product Specifications

CAS Number

[311795-38-7]

Product Name Alternative

Compound 968

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Glutaminase-C-IN-1.html

Purity

99.89

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C(C(C2=CC=C(N(C)C)C(Br)=C2)NC3=C4C5=CC=CC=C5C=C3)=C4CC(C)(C)C1

Molecular Formula

C27H27BrN2O

Molecular Weight

475.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112 (2) :394-9.|[2]Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18 (3) :207-19.