CCT241736
CCT241736 is a potent and orally active and dual FLT3-Aurora inhibitor. CCT241736 has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively. CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I. In cellular assays, CCT241736 inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 and MV-4;11 with EC50 values of 0.1 and 0.27.
Product Specifications
CAS Number
1402709-93-6
Product Name Alternative
CCT241736 | CCT-241736 | CCT 241736
Purity
>98% (HPLC)
Solubility
DMSO : 75 mg/mL 164.34 mM; H2O : < 0.1 mg/mL
Smiles
Cc5nn (C) cc5c3nc4ncc (Cl) c (N2CCN (Cc1ccc (Cl) cc1) CC2) c4n3
Molecular Formula
C22H23Cl2N7
Molecular Weight
456.37
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-chloro-7-[4-[ (4-chlorophenyl) methyl]-1-piperazinyl]-2- (1,3-dimethyl-1H-pyrazol-4-yl) -3H-imidazo[4,5-b]pyridine
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