PHCCC
PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.
Product Specifications
CAS Number
179068-02-1
Product Name Alternative
PHCCC
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 32 mg/mL; 108.73 mM
Smiles
C12 (C (/C (=N/O) /c3ccccc3O1) C2) C (=O) Nc1ccccc1
Molecular Formula
C17H14N2O3
Molecular Weight
294.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -7- (hydroxyimino) -N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a (1H) -carboxamide
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