Picropodophyllin
Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT) . This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis.
Product Specifications
CAS Number
477-47-4
Product Name Alternative
AXL1717 | AXL-1717 | AXL 1717 | PPP | picropodophyllin
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 120.65 mM
Smiles
COc1cc (cc (c1OC) OC) [C@H]1[C@H]2[C@H] (COC2=O) [C@H] (c2cc3c (cc12) OCO3) O
Molecular Formula
C22H22O8
Molecular Weight
414.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(5R,5aS,8aR,9R) -9-hydroxy-5- (3,4,5-trimethoxyphenyl) -5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6 (8H) -one
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