Vorapaxar sulfate
Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist. (In Vitro) :Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
Product Specifications
CAS Number
705260-08-8
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (211.63 mM)
Smiles
S (=O) (=O) (O) O.Fc1cc (c2cnc (/C=C/[C@@H]3[C@H]4[C@@H] (C[C@H]5[C@H]3CC[C@@H] (NC (=O) OCC) C5) C (=O) O[C@@H]4C) cc2) ccc1
Molecular Formula
C29H35FN2O8S
Molecular Weight
590.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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