Sobetirome

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM) . (In Vivo) :Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ) - and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10x Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20x Sobetirome (GC-1) induces a decrease in fat mass of 20%.