Sobetirome
Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM) . (In Vivo) :Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ) - and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10x Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20x Sobetirome (GC-1) induces a decrease in fat mass of 20%.
Product Specifications
CAS Number
211110-63-3
Product Name Alternative
QRX-431 | IACS-010759
Purity
>98% (HPLC)
Solubility
DMSO: 30 mg/mL (91.4 mM) ; Ethanol: 30 mg/mL
Smiles
CC (C) c1cc (Cc2c (C) cc (OCC (O) =O) cc2C) ccc1O
Molecular Formula
C20H24O4
Molecular Weight
328.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4- (4-hydroxy-3-isopropylbenzyl) -35-dimethylphenoxy) acetic acid
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CDC42 Binding Protein Kinase alpha (CDC42-binding Protein Kinase alpha, DMPK-like alpha, CDC42BPA, FLJ23347, KIAA0451, Myotonic Dystrophy Kinase-related CDC42-binding Kinase alpha, Myotonic Dystrophy Protein Kinase-like alpha, Serine/threonine-protein Kinase MRCK alpha, MRCK alpha) (Azide Free) (MaxLight 490)