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M8-B Hydrochloride

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

Product Specifications

CAS Number

883976-12-3

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 250 mg/mL (577.42 mM)

Smiles

Cl.COc1cc (CN (CCN) C (=O) c2cccs2) ccc1OCc1ccccc1

Molecular Formula

C22H25ClN2O3S?

Molecular Weight

432.96

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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